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Artificial intelligence is accelerating cyberthreats by enabling adversaries to find unknown software flaws and execute attacks faster than ever before. Because much of America’s critical infrastructure relies on aging, under-resourced systems, the risk of catastrophic disruption is growing rapidly. However, a “defender’s window” is currently open, giving trusted defenders a brief advantage to use advanced AI tools to patch vulnerabilities first. Capitalizing on this moment requires radical partnerships where leading AI labs, the intelligence community, and academia cooperate closely. Critical operators also need hands-on technical support, training, and global alliance expansion to ensure vulnerabilities are effectively fixed before attackers catch up.