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A team at Microsoft says it used artificial intelligence to discover a “zero day” vulnerability in the biosecurity systems used to prevent the misuse of DNA. These screening systems are designed to stop people from purchasing genetic sequences that could be used to create deadly toxins or pathogens. But now researchers led by Microsoft’s chief scientist, Eric Horvitz, say they have figured out how to bypass the protections in a way previously unknown to defenders. The team described its work today in the journal Science. Horvitz and his team focused on generative AI algorithms that propose new protein shapes. These types of programs are already fueling the hunt for new drugs at well-funded startups like Generate Biomedicines and Isomorphic Labs, a spinout of Google.